Pistol type? Fixed or adjustable sights?
Lighter bullets at significantly higher velocities will frequently shoot quite low (compared to point of aim). Most fixed sight handguns are regulated for "standard" ammunition in the caliber chambered. In .45 ACP that usually means 230-grain bullets.
Before relying upon the 185-grain loads, make a trip to the range. Check point of impact, as compared to point of aim. Also, run two or three magazines full through the pistol (from each magazine you will be using) to make sure that the ammunition will feed, fire, extract, and eject reliably.
The differences between high velocity hollow points and low velocity hardball can be argued forever. But, the bullet that hits the target is the one that ends the fight. Reliability and accuracy are the gold standard; everything else is a **** shoot.
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