First off, the Python like the k-frame S&W
is a medium frame not a large frame revolver. That being said, the 686 would be more forgiving if you plan on shooting handloaded ammunition as the Colt's cylinder is a bit shorter. It will handle all commercial ammo, as far as I know, but some handloads with long nosed SWC bullets won't allow the cylinder to close unless you crimp forward of the crimping groove.
The hand fitted action on the older Colts is a thing of wonder but the same can be said of the old 27's. As a shooter, I prefer the S&W trigger pull but the Python is truly lovely.
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Big bang, much smash'em.
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