Why I even read that it could cure cancer!
(Just kidding!)
It will work fine in the calibers you have listed. It isn't going to be a favorite powder in any of them if you use new data though. It just won't work well at the "lawerized" loads that you will find in most manuals today.
Since FT has used it for so long maybe he would share some of the loads he has developed with you through PM's.
I know there are lots of folks that have used what would be considered +P+ loads with it safely for a long, long time.
I have limited experience with it. I have used it but find that there are better suited powders for each of my specific needs.
The mental image that I get when I hear "Unique" is one size fits all. Like back in the '60s when the MOOMOO dress came out. They surely would fit ALL but none well.
That is just my opinion, don't shoot me over it!