I use alot of IMR 4227 in handguns, but not the .357.

In the .44 Magnum shoot 25.0 under a 250 Grain Lyman / Keith and 26.0 under a 200 Grn. Hornady XTP.

Both loads are extremely accurate in 4" 29's and the XTP load very effective on deer. A pal of ours used this load to "finish" a Virginia Whitetail with a headshot from about 30'. Without being too graphic, that XTP exposed the cranial vault and neither ear was ever found.