Cloudpeak;
I have a couple of 625's chambered in .45 ACP. I mostly shoot them with target loads (200 SWC cast bullets ahead of 4.0 grs of Bullseye or equivalent). However, it will also safely handle the Lyman 452424 Keith 250 gr SWC at 900 fps. That is equal to the original .45 Colt ballistics with a MUCH more effective bullet. If I need any more than that I break out my .44 Magnums.

I load my heavy loads in .45 Auto Rim cases just to make certain that they will not find themselves in one of my 1911 platforms (although with the bullets distinctive shape what would not be liable to happen).

FWIW
Dale53