My 325 Night Guard will fire Remington 230gr Ball, and 230 Golden Sabre HP with out the clips. However several other factory 45 ACP's will not reliabley fire without the clips.

I would not hesitate to shoot 45 Super in any Steel framed S&W 45 ACP revolver.

I do not think I would shoot a lot of it in a Scandium framed gun...

I know they make the Scandium guns in 44 mag, but they have had some problems with them.

Also if you have a steel framed 45 ACP take a look at Buffalo Bore +P Auto Rim ammo.