Don't really understand why you would even consider carrying a .25 for self defense when in the same sized package you could get a .380 (which IMHO is still under powered for self defense work), but a noticeable improvement. If a .25 is the only gun you own and could not afford to purchase a more powerful weapon, than I suppose it is better than a knife.

I know there have been lots of people killed with .22's & .25's, but the idea behind a defense gun is to stop the threat as soon as possible, not have the perp. simply die hours later after he has inflicted bodily harm on you.

I own .22, .25, .32 & .380 caliber guns, but NEVER use them for self defense work. My gun of choice is either a Model 65 .357 or a Model 60 stoked with Buffalo Bore 158 Gr. +P ammo.

As Handejector states, when is the last time you were threatened by water filled milk jugs?