It really depends on what you want to do. For an all around powder, yup, Unique is the clear winner. For 38 Special, W231 and Bullseye are worthy choices. 357 is an entirely different animal if you are loading for maximum power, however. H110/W296 and the right bullet will get you a serious "magnum" load. 2400 must be mentioned also as an excellent, versatile powder.