The answer to your question is NO. Remington's factory acceptance standards for the 40X were .10" tighter for the .223.

That said, I would chose the .22/250 as a coyote gun, if coyotes at 300+ were the primary target.

In the VTR, I doubt if you could see the accuracy difference.

Remember the three Bs- Bullets, bedding, barrels.

Good shooting.