In my experience, IMR 3031 does very well in .30-06 with bullets up to 150 grains. Heavier bullets generally benefit from slower burning powders.
I used Speer 130 grain HotCor bullets in .30-06 for antelope hunting very successfully. Antelope are light and thin-skinned game, usually hunted in open country. Our other game animals here in Colorado include mule deer and elk, usually hunted in brush and timber, for which I prefer heavier bullets.
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