Accept for accuracy. I've had 2 .22-250's and 1 .223 in bolt rifles. Hands down the little .223 gives better accuracy.

Depends what you want to do though. To me the .223 is a 250 yard cartridge. Goes farther then that but beyond 250 yards and I'd pick one of my other rifles preferably the .25-06 which I consider one of the best varmint rounds for long range.