An advantage? No. At a disadvantage, no unless at I was a shooting competition that stacked the deck in favor of high capacity autos. When working cases where a vehicle take down is likely I usually have a 4" .357 in addition to everything else. Please don't beat up the rifle/ shotgun / thermo nuke is better argument, I know. I also know shootouts are very fluid and unfold rapidly. I might not get to my long gun and I prefer the penetration of a .357 on auto bodies over my.45's. I wear both when working.