GOV5, don't aim center mass. Aim for the upper chest. A .380 through the aorta will start the shut down process, or end hostilities immediately. Cartridges like the .357 magnum, .45 ACP ect. will, at times, turn marginal hits into stops whereas the .380 and other mouse gun cartridges are much less likely to do so. Carry a .380 as a BUG, or when nothing bigger will work.