Not sure the full size 40 will be much different, but the 40c is my CC weapon of choice. Admittedly, this is my first one, however, I've had very few issues carrying this on me the entire day, comfortably. I'm assuming that you will be carrying IWB concealed. And I'm assuming that you've worked out the bugs in terms of your waist size, the type of IWB holster(s), belt, slightly larger pants, etc., etc., you will need to consider.

We all know that there are many other smaller pistols for CC that are available, but since I'm able to carry my 40c comfortably, I don't regret for a second my decision.