I have a client who is an older lady who is left handed. She recently bought a S&W 442 revolver and was showing it to me. She had shot it a few times and said she did pretty well with it. She shot it with her right hand and pulled the trigger with her middle finger. Apparently the BC gap didn't cause a problem for her. When I asked her why she used her non-dominant hand and middle finger she said that was where she was strongest. She also throws darts (not very well) with her right hand, although for almost everything else she uses her dominant (left) hand.
I suspect age may be an issue, as well as her small stature, but she says it works for her. We plan to go shooting soon so I guess I'll see first hand.