John Linebaugh's articles on loading heavy .45 Colt's will have the information you desire. The S&W will not take "Ruger Only" loads but can be loaded to give excellent results for deer. John's wife uses an S&W for hunting deer and antelope.

John carries a Smith .45 Colt on a daily basis. Scroll down to the bottom of the article for his comments on the Smith. I tend toward the conservative side of the coin and John's suggestions to hold the load's at 5% below the listed loads sounds good to me.

Linebaugh's Custom Sixguns - Heavyweight Bullets

FWIW
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