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But all else being equal, 45 LC loads that are not any hotter than moderate 44 Mag loads are not going to be any more detrimental to an N-Frame than those same 44 Mag loads would be, IMO.
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This makes sense. I can't believe that S&W has separate heat treating for N-Frames and their cylinders, depending on what caliber they are. It seems like such a system would be terribly error-prone and require much more effort than just doing them all the same at the same time. If anyone has any reliable information to the contrary, please speak up.
I would not hesitate to occaisionally shoot .45 Colt +P through a
MODERN S&W. If I frequently required that power level, I would get a Ruger or better still just get a Model 29 and be done with it.