I checked some Unique loads a few years ago and found 5.5 gr to be a little more than standard loads, but certainly less than .38-44 loads by a good amount. The gun used seemed to make a lot of difference in the velocity of the two lots of powder. One lot was from the 1930s or 1940s and the other lot was 2005.
You'll notice I did shoot these out of a 1949 M&P with no ill effects to the gun.