I know 3 people who carry a .22 revolver for their Pocket CCW.
One of them has rat shot cartridges for the first two - mostly for snakes but said if had to use to defend self / family against deadly threat; "How many people would still be a threat after being shot in the face with snake shot - followed by 3 to Center Body Mass?"
Sounded good to me - but I'll stick with my .45 or .38.
I believe this link shows the revolvers they carry:
North American Arms