I use 23 gr of 4227 with 250gr cast SWCs. I also use CCI350 primers. I do not get an unusual amount of unburned powder. No more than with 2400. This load shoots well in anything I've tried it in, including carbines.

This load gives 1250 fps in my 2 6-1/2" M29s. A little more in a 7-1/2" Redhawk. Velocity with this load is up there in the magnum category, but recoil seems more like a shove than the jolt 2400 loads seem to give in the same velocity range. I like this load in my old 29's for this reason. Could be my imagination, but I don't think so.

I found out years ago during the silhouette days, along with others, that 4227 seems to be a little easier on guns than other powders (296/H110) when considering flame cutting and forcing cone erosion.