They don't relate to hand-size.
K and L have a grip-size that most people will find comfortable. K and L are S&W's "Medium" frame.
N's grip is a touch larger than K/L (about 1/4" longer trigger reach) and is S&W's "Large" frame.
There's the X-frame (S&W's "extra-large" frame) which actually shares the grip frame of the K/L-frame (thus it'll have the same grip size).
There's the J-frame, S&W's small frame, which is meant for CCW/Kit-gun type revolvers.
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