Hrm~too bad about the troubles you're having,I've had my 4506-1 about a half year and have maybe 200 rounds through it,but like your 4506 I think it'll eat anything!
One thing to take note of:I've heard from all over that the .45 doesn't take well to a miniaturized pistol they ALL have problems of one sort or another.
The Glock though.....those things seem to always work