I've about settled on 2400 for full-powered .357 Magnum loads. I have loaded quite a few batches of 158 grain bullets over a healthy charge of H110 and it gives good performance. These would mostly be used in N-Frame guns.

When I had a 4-inch K-Frame Model 19 I liked the 2400 load in it and also had a respectable .357 Magnum load built around Unique.

I've tried a couple of boxes of lighter bullets for handloading .357 Magnum but never really used them much. I like heavier bullets better and never completely bought into the notion of the wonders of the 125 grain load.