This is the problem in working with a powder manufacturer vs a bullet maker. the data will be different as it always has. Hodgon's website indicated this for the 125 gr Hornady bullet...

125 GR. HDY XTP Hodgdon H110

21.0 MIN 38,400 CUP

22.0 MAX 41,400 CUP

The Hornady manual shows 17.4 as a minimum start and 19.9 as max. So, Hodgdon is recommending a start charge greater than Hornady's max charge with the same bullet. If I used the hypothetical bullet/powder I stated earlier with 18.5 gr with this bullet, that is a bit under minimum, according to Hodgdon.

I think you should use the bullet manufacture's suggestion over the powder manufacturer's call. Nevertheless, I won't be using H110 anyway(or W-296) if and when I can find a 66-2 or -3.
I have several older manuals and none of them, including Speer's #9, have any reloading data for the 38 Special +P. Their latest#14 does and I overlooked that. Hornady's #7 doesn't have any data.

It would be great to be able to shoot lead bullets but unfortunately, such is not the case. I use to shoot them in an old M28 back in the '70's and I feel sure I used H 110 and probably 296 and 2400. However, that was in an N-frame.

I think the model 66 would be better for me in that I now find the larger frames just too big for some reason. Maybe the difference in being 35 vs 65. There is quite a difference.

DaveT-Never used the plated versions and all I understand about them is that some are not consistent in weight/diameter and can only be driven just so fast. I have to plead ignorance with these bullets.