This is why so many great pistols are made in great calibers. I don't think there is a perfect combo for all uses. For me, the 45ACP is the best all around cal. My CCW is a ten shot PT 145, house gun is a Colt 1911, and at the range I use a 25-5 and a 1917 Classic so I don't go chasing the cases. Of course many other guns and calibers go to the range with me and my hunting stuff is different yet. But, if you need to put a hole in something why not put a big hole in it?