I'm anxious to see the comments on your post, as I just purchased a 460 myself. I have reloaded for about 20yrs off and on, so I'm as curiuos as most in the performance of this gun with the three calibers. I have read in several forums,different opinions and performance claims in firing all three calibers-from "don't bother with the 45LC" to "I haven't had any issues with any three calibers". It may be a "personal" thing when it comes to quality of performance with this gun when firing all three calibers thru it, but so far I haven't read about anyone having concerns about forcing cone breakdown, but I guess that will depend on the load.