I purchased a M29-10 that the alignment of the flutes didn't match up correctly with the charge holes.
I had bought it because it had a excellent bright nickle finish, and a great trigger pull.
After a few days I noticed that when looking from the top the cylinder didn't look lined up with the barrel.
After examining it carefully I realized that the alignment of the flutes was off, but the charge holes did align with the bore.
I called Smith & Wesson as I was worried about the strength of the cylinder, but they told me that it wasn't a problem and it wouldn't weaken the cylinder, that it would be safe to shoot.
I thought that they would at least want to check it but they said no, it would be fine.
So I loaded some test rounds, starting light and worked up to some heavy loads, testing each charge hole one at a time and it was fine.
It turned out to be a very accurate revolver