Back in the 1980's I did some tests to equal Remington's 158 grain softpoint load in both a 4" revolver and a Marlin 1894.
In the Marlin the Remington load chronographed at 1754fps.
In a model 19 it was closer to 1100fps but the 19 gives less velocity than my 686 with all loads. I tried 16 grains of H110 with a 160 grain Speer softpoint. Velocity was 1660fps in the Marlin and 1040fps in the 19.
At 17 grains of H110 the velocity equaled the Reminton load at 1756,1748,1764fps. I did not shoot that load in the 19. At 17 grains of H110 you will notice that the primers are really flattened out.
I later tried a 158JHC Sierra bullet with 16 grains of H110 CCI mag primer in my 686 and velocity ran 1167,1165,1173fps.
That is very consistant.
Now there is another load which will produce consistant velocities
in my 686 and that was 11 grains of Bluedot.
With a 158JHC Sierra velocities ran 1226,1251,1220fps.
These loads are hot and will flatten primers.
I like but have discontinued using Bluedot. I have recently shot some AA#7 and this powder produces no noticable flash like BD and H110.
I wish I had some data to share on the AA powders as this may be the way to go in the future.
I still load 16 grains of H110 for the rifle and the 686.
I keep hoping someone has run some AA powders over the chronograph as I would love to see the data.

I hope that this was helpful to you.

Bruce