No! What most people who consider themselves "sixgunners" want is the S&W equivalent of the Model 29 that will stand up to a true .45-caliber magnum, like the .454 Casull cartridge, in basically the same fashion the 29 does with the original 44 Magnum. (At least among the folks I know.)

Beyond that power level, the gun will cease to be a sixgun and becomes more a mutation between handgun and carbine, doing the job of neither as well as the other two.

Not being an engineer, I can only theorize, but it would seem possible to make a slightly beefier gun, similar to an N-frame, that would still be practical to wear on a belt, for the (mythic) "average size man." The X-frame is just too big and too heavy to be practical.

Having to tune up a finely made gun every 3000 or so rounds is really no great hardship. The Model 29 does what it does just fine. Let's not tamper with it.