IMO if you have the right gun, meaning an N frame, L frame, or a Ruger, 14.0 to 14.5 grains of 2400 pushing the 158 grain bullet is okay, but work up to it and don't start there. It is a pretty stout load at 14.5, and will cause flattened primers, but there are factory loads that flatten them more. I've shot 14.5 with a 173 grain Keith through a couple of 686s and they seem to be none the worse for it.
I no longer shoot stuff this hot in any K frame, just on general principles, and keep my max loads for K frames at about 1150-1200 fps (calculated).

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Geoff. Since 1960.