You can set your sights up any way you want. You can aim at the 6 O'clock position and have the bullets go into the bulls eye.
You could even have your sights 1 inch right and 1 inch low and have your bullets go to center. It does not matter.
It sure will mess with the next shooter tho.
Whatever sight picture works for you is the one you should use. That's why there are HUNDREDS of different sights on the market.