Have a mid-size (4") .45 and even with large hands, prefer the small, since my EDC is usually a 1911.

At the LGS where I work, I've sold 2 to customers who, due to industrial accidents, have lost portions of their hands/fingers. They were thrilled with the feeling of the 9's/.40's with NO grip panel.

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Ret'd LEO
SWCA #2275