I have shoot a lot of different .22lr rifles over the years. I sight in bulls eye at 25 yards. Bulls eye at 50 yards I hold just a little low. ~.5 inch. At 75 yards just right over, and 100yards about 3 inchs over.
Done me well, getting the first shot close. Each rifle, and each brand of ammo will hit a little bit different. You have too walk it in.
What I have been playing lately is golf. Golf ball teed up at 50yards. You get five shots with .22lr open sights, to see who can move it on down the most. Best I have done 76 yards. Got beat the other day by 81 yards.

It is fun!!!

Guy22