I am firmly committed to the 17 HMR....and my Savage rifle that shoots it...I am a lefty and my rifle is a righty, but we work it out somehow....
It is a supreme squirrel slayer, especially with the 17 grain pills...the 20s do a good job too....but my rifle loves the 17's more.
I have a SWR Spectre can on mine....which quiets the noise a bit in spite of the supersonic ammo....
I rarely shoot many of my 22LR rifles anymore for anything other than plinking...anything my LR rifles can do my 17 HMR seems to do better....and I have a good stock of ammo, so my 17 gets "the call" most of the time