These are the heaviest loads I have found in the loading books I have.
From the Lyman 45th Edition, and the Lyman Cast Bullet Handbook from @1973.
With a 150gr plain base, or a 158gr gas checked Cast bullet they start with
4 grains of Unique for velocities @690fps.
MAX is 8gr of Unique for velocities of 1280fps for the 150gr and 1250fps for the 158gr.
These are from a 5" S&W Mod 27.
They also show 15gr of 2400 [this would be the Old 2400] as MAX with similar velocities.
Hope this helps.
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