I had a 4566TSW, shot low for me, and 2 other people who tried it--one being an experienced shooter. I contacted S&W and they sent pre-paid label and replaced the front sight with a shorter one. It was better then I got it back, but I still had accuracy issues with the gun. Either the grip angle, gun itself, or me--but it wasn't the gun for me, as I couldn't get better than buckshot accuracy out of it.

You might try adding a set of Hogue grips to fit your hand better.