550B here reloading at least 9 different calibers. That's the beauty of the 550. OTOH, I've seen other people setup with 4 or 5 450, each dedicated to a caliber. Craziest setup I've seen is a guy with 4 650...
As others have pointed out, it is wise to stay away from auto-indexing when starting out.
I'd jump on the 450 if it was me.
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