I've loaded with every Dillon up to the 1050, have always had my 550 set up - however, I dislike the priming system so much that I prep and prime all my brass on a trusty Rock Chucker. While this may sound time consuming, it really isn't. I load a LOT of calibers, from 32 S&W to 50 AE, and the 550 works fine. If you're serious, get a bunch of toolheads so you can set each caliber up and swap them quickly