Back when the 243 was conceived, it was thought that velocity was the key to killing. In a way it is, but you also need mass behind that velocity. The 243 was meant to be a varmint gun in the spring and a deer gun in the fall for that 1 rifle guy. The 243 is an excellent varmint to deer round and has put alot of meat on the table and heads on the wall. The 25-06 is not in the same league though. It is a flat shooting round that was originally meant for long range hunting - 400+yards, on deer sized game. It will take about any game in the US. I would not use it on big bears but it could with the heavier bullets and a good shot. What it really comes down to is what you are comfortable shooting. If a 25-06 is too much recoil the step it down. I personally like the 257Roberts as a medium round. Less recoil than the 30-06 and some flexibility in light weight bullets. Either way, the 243 or 25-06 will take a deer down with a perfect shot under 250 yds. Out past that then step it up to the 25-06.
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