I have owned several S&W handguns in both rounds. I tested the 460 and 500 Mag extensively. Without a doubt the 500 Mag is far superior to the 460 Mag in my opinion. A bigger hole is always better. 275 to 700 gr. bullets out of a 500 Mag, larger holes, more energy. I picked the 500 mag over the 460, and don't look back!
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Endowment Life Member NRA
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