CCI Velociters and Stingers can be used in any .22 LR caliber handgun or rifle unless the manufacture of the firearm states otherwise .

The Smith and Wesson model 43 C should be able to handle all 22 lr, long, and short cartridges without any problems.

I also believe that Smith and Wesson has a life time warranty on its firearms.

It is really difficult to wear out a quality .22 handgun or rifle. I have a model 41 Smith made in the early 90's, and I have well over 20,000 rounds through it mostly hi velocity ammo, the bulk pack variety. Nothing has ever broke and it still works great. I also noticed no wear in the barrel and it probably shoots more accurately today than when new.

al