For me it depends solely on the gun... in large part the ergonomics (I think that is the correct term). Years ago I picked up a WWII vintage 32 Mauser that was like pointing a finger. It shot exactly where I looked. I have a Colt Woodsman that is the same way... it is instinctive. My 1911 Colt took lots of practice and still takes some concentration. Some revolvers are the same way. My 66 and 686 2.5" guns just won't miss while some other revolvers seem to have a steeper learning curve. In addition to the shape of the gun/grip/barrel I find certain sights easier and certain triggers more natural. My Sigs (239, 226, & 220) are kind of midway on the learning curve.
So, I don't think there is any right answer to your question. Go for the gun that feels natural to you and just wants to put 'em in the X ring to please you.