My choice in .45 would be the 4566 by far. The 4506 is a great piece so long as one never straps it on. For those of us who want a 4506 when the need to leave the house arises the 4566 is the better option.
For 9mm, I agree the 5903 is superior to the 5906. I believe the steel framed 9mm is a work of art, but I don't have to carry it either.
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