It is absolutely different....I know we can hot rod little guns and get them to really sting our hand...like the little j frames or even the 329pd 44mag. But Nothing will equal the power generated by the huge mass of a 350 or a 450 grain bullet leaving in a hurry.
Now take the 400grain bullet and send it at a scorching 1805 fps...you will get all of the snap and high speed recoil of the little guns plus the inertia of 400 grains of lead leaving in a hurrry.
I'll finish by saying the 500 is not really that bad and I really enjoy shooting my 4" with 350 Berry's/xtp's and 450Kieth's....but 1000fps is the sweet spot. You never really escape the force generated by the bullet's mass...there is nothing that compares or feels like a huge bullet leaving, I don't care how hot you load a 357.