I say the .45, but across the spectrum, pistols to rifles, I am a moderate velocity heavy bullet guy. That said the .357, .45, 10mm, .44Spc & Mag are the Major league players. I like a .45 or .44 better than a .357 (for several reasons, hearing and recoil among them), but I like the .357 better than the 9mm and its ilk of bush leaguers, and as it happens I'm carrying a .357 today.
I guess what I'm saying is if I knew I was going to get into something, I would opt for a Government .45, but walking around not knowing whether anything will happen and carrying a 66 .357 doesn't bother me.
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