Raw or cooked? Frozen? I ask that in seriousness, since raw would be tougher than cooked, and frozen even more so. I am not sure of the velocity off hand, but I would not be surprised to find that the velocity from the 10/22 at 300 yards is not much different from that provided by a 2" revolver at 3-5 yards.
I suspect I would want a good solid point, as much like a SWC as possible, so that there is a real chance of penetration to the vitals. A lot of the target zone on a human is covered by bone.

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NHI, 10-8.