I love the old description of Unique... flammable dirt.

I use it, but mostly in 45 colt and occasionally in work-up loads for other large bore calibers like .44Spl. Good for the 45-70 too, but so is 2400 and IMR 4227.

In the .38/.357 I like two mainly - W231/HP38 for light to +P and W296/H110 for magnum.

I have found 2400 to be really good in .357 for hot loads, I really do like it, but I'm one of those guys that limits the powder options so that I don't have too many different powders laying about.