The extra energy of +P cannot be ignored. As mentioned above, even 100 fps in the energy equation makes a significant difference. That said, I mostly use standard pressure ammo in my 45s. A good 45 ACP SD load at standard pressure is very powerful, and I prefer the controllability that it gives me over +P. The only carry combination I have ever tried that I was uncomfortable with was +P Rangers in a Kimber Ultra Carry II. That was down right painful to shoot, and not very controlable at all!

Remember, you can't miss fast enough to win. Pick a load that allows you good performance and the confidence to make hits on target.