IMHO for home defense... first choice - shotgun with #4 buck shot, second choice choice - 9mm or larger handgun with quality JHP ammo tested for correct function, no other choice - 22 caliber anything. All my rifles are bolt-action hunting rifles and almost any rifle larger than a .22 will definitely penetrate more than the other choices. In my home, I have no way to adequately secure my shotguns from young grand children other than the safe, so my actual first choice is my carry pistol on my person, or my .40 S&W in a discrete quick access lock box.
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