You are going from Universal/Unique (31 and 32 on the Hodgdon powder burn rate chart) to a faster powder and a very very slow powder.
There are so many good powders in between, I'm just curious how you picked those two? I always start by looking at the bullet, velocity and pressure I want to start with. Then I pick a powder that seem to match what I want as a result. Both 231 and 296 are great powders. But I would never use 231 for a load I would even consider 296 for.
Personally I much prefer 2400 over 296/H110. It is just more forgiving and you can load it over a much wider range. 296/H110 is great for full load applications that you don't want to deviate from. Otherwise you risk squibs or lots of unburned powders.
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